TY - JOUR T1 - The effect of smoking on lung function: a clinical study of adult-onset asthma JF - European Respiratory Journal JO - Eur Respir J SP - 1298 LP - 1306 DO - 10.1183/13993003.00850-2016 VL - 48 IS - 5 AU - Minna Tommola AU - Pinja Ilmarinen AU - Leena E. Tuomisto AU - Jussi Haanpää AU - Terhi Kankaanranta AU - Onni Niemelä AU - Hannu Kankaanranta Y1 - 2016/11/01 UR - http://erj.ersjournals.com/content/48/5/1298.abstract N2 - The aim of this study was to evaluate the effect of smoking on lung function decline in adult-onset asthma in a clinical, 12-year follow-up study.In the Seinäjoki Adult Asthma Study, 203 patients were followed for 12 years (1999–2013) after diagnosis of new-onset adult asthma. Patients were divided into two groups based on smoking history: <10 or ≥10 pack-years. Spirometry evaluation points were: 1) baseline, 2) the maximum lung function during the first 2.5 years after diagnosis (Max0–2.5) and 3) after 12 years of follow-up.Between Max0–2.5 and follow-up, the median annual decline in absolute forced expiratory volume in 1 s (FEV1) was 36 mL in the group of patients with <10 pack-years of smoking and 54 mL in those with smoking history ≥10 pack-years (p=0.003). The annual declines in FEV1 % pred (p=0.006), forced vital capacity (FVC) (p=0.035) and FEV1/FVC (p=0.045) were also accelerated in the group of patients with ≥10 pack-years smoked. In multivariate regression analysis, smoking history ≥10 pack-years became a significant predictor of accelerated decline in FEV1.Among patients with clinically defined adult-onset asthma, smoking history ≥10 pack-years is associated with accelerated loss of lung function.In adult-onset asthma, smoking history ≥10 pack-years is associated with accelerated loss of lung function http://ow.ly/zZep302fJob ER -