PT - JOURNAL ARTICLE AU - Sin, Don D. AU - Miravitlles, Marc AU - Mannino, David M. AU - Soriano, Joan B. AU - Price, David AU - Celli, Bartolome R. AU - Leung, Janice M. AU - Nakano, Yasutaka AU - Park, Hye Yun AU - Wark, Peter A. AU - Wechsler, Michael E. TI - What is asthma−COPD overlap syndrome? Towards a consensus definition from a round table discussion AID - 10.1183/13993003.00436-2016 DP - 2016 Sep 01 TA - European Respiratory Journal PG - 664--673 VI - 48 IP - 3 4099 - http://erj.ersjournals.com/content/48/3/664.short 4100 - http://erj.ersjournals.com/content/48/3/664.full SO - Eur Respir J2016 Sep 01; 48 AB - Patients with asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS) have been largely excluded from pivotal therapeutic trials and, as a result, its treatment remains poorly defined and lacking firm evidence. To date, there is no universally accepted definition of ACOS, which has made it difficult to understand its epidemiology or pathophysiology. Despite many uncertainties, there is emerging agreement that some of the key features of ACOS include persistent airflow limitation in symptomatic individuals 40 years of age and older, a well-documented history of asthma in childhood or early adulthood and a significant exposure history to cigarette or biomass smoke. In this perspective, we propose a case definition of ACOS that incorporates these key features in a parsimonious algorithm that may enable clinicians to better diagnose patients with ACOS and most importantly enable researchers to design therapeutic and clinical studies to elucidate its epidemiology and pathophysiology and to ascertain its optimal management strategies.We propose that asthma-COPD overlap syndrome be defined based on three major criteria and one minor criterion http://ow.ly/3rOU304aTNm