RT Journal Article
SR Electronic
T1 Bronchodilator response following methacholine-induced bronchoconstriction predicts acute asthma exacerbations
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 104
OP 114
DO 10.1183/13993003.00182-2016
VO 48
IS 1
A1 Heung-Woo Park
A1 Woo-Jung Song
A1 Yoon-Suk Chang
A1 Sang-Heon Cho
A1 Soma Datta
A1 Scott T. Weiss
A1 Kelan G. Tantisira
YR 2016
UL http://erj.ersjournals.com/content/48/1/104.abstract
AB Methacholine bronchial provocation test provides the concentration of methacholine causing a 20% decrease in forced expiratory volume in 1 s (FEV1) from baseline (PC20). The dose–response slope (DRS), and other continuous indices of responsiveness (CIR; the percentage decline from the post-diluent baseline FEV1 after the last dose of methacholine), and per cent recovery index (PRI; the percentage increase from the maximally reduced FEV1 after bronchodilator inhalation) are alternative measures. The clinical relevance of these indices in predicting acute asthma exacerbations has not been fully evaluated.In two prospective cohorts of childhood and elderly asthmatics, baseline PC20, DRS, CIR and PRI were measured and evaluated as predictors of acute asthma exacerbations.We found that PRI was significantly related to the presence of asthma exacerbations during the first year of follow-up in both cohorts of childhood (p=0.025) and elderly asthmatics (p=0.003). In addition, PRI showed a significant association with the total number of steroid bursts during 4.3 years of follow-up in the cohort of childhood asthmatics (p=0.04).We demonstrated that PRI, an index of reversibility following methacholine-induced bronchoconstriction, was a good clinical predictor of acute exacerbations of asthma in both childhood and elderly asthmatics.Bronchodilator response following methacholine-induced bronchoconstriction may predict acute asthma exacerbations http://ow.ly/ZguI2