PT  - JOURNAL ARTICLE
AU  - Julia Hoffmann
AU  - Jochen Wilhelm
AU  - Andrea Olschewski
AU  - Grazyna Kwapiszewska
TI  - Microarray analysis in pulmonary hypertension
AID  - 10.1183/13993003.02030-2015
DP  - 2016 Jul 01
TA  - European Respiratory Journal
PG  - 229--241
VI  - 48
IP  - 1
4099  - http://erj.ersjournals.com/content/48/1/229.short
4100  - http://erj.ersjournals.com/content/48/1/229.full
SO  - Eur Respir J2016 Jul 01; 48
AB  - Microarrays are a powerful and effective tool that allows the detection of genome-wide gene expression differences between controls and disease conditions. They have been broadly applied to investigate the pathobiology of diverse forms of pulmonary hypertension, namely group 1, including patients with idiopathic pulmonary arterial hypertension, and group 3, including pulmonary hypertension associated with chronic lung diseases such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. To date, numerous human microarray studies have been conducted to analyse global (lung homogenate samples), compartment-specific (laser capture microdissection), cell type-specific (isolated primary cells) and circulating cell (peripheral blood) expression profiles. Combined, they provide important information on development, progression and the end-stage disease. In the future, system biology approaches, expression of noncoding RNAs that regulate coding RNAs, and direct comparison between animal models and human disease might be of importance.Comprehensive overview of compartment-specific microarray studies of material from pulmonary hypertension patients http://ow.ly/YEFO2