PT  - JOURNAL ARTICLE
AU  - Lei Gao
AU  - Liqiong Bai
AU  - Jianmin Liu
AU  - Wei Lu
AU  - Xinhua Wang
AU  - Xiangwei Li
AU  - Jiang Du
AU  - Xinchun Chen
AU  - Haoran Zhang
AU  - Henan Xin
AU  - Hongtao Sui
AU  - Hengjing Li
AU  - Haoxiang Su
AU  - Jian He
AU  - Shouguo Pan
AU  - Hong Peng
AU  - Zuhui Xu
AU  - Antonino Catanzaro
AU  - Thomas G. Evans
AU  - Zongde Zhang
AU  - Yu Ma
AU  - Mufei Li
AU  - Boxuan Feng
AU  - Zhen Li
AU  - Ling Guan
AU  - Fei Shen
AU  - Zhijian Wang
AU  - Tao Zhu
AU  - Shumin Yang
AU  - Hongyan Si
AU  - Yi Wang
AU  - Yunhong Tan
AU  - Tianzhu Chen
AU  - Chen Chen
AU  - Yinyin Xia
AU  - Shiming Cheng
AU  - Weiguo Xu
AU  - Qi Jin
TI  - Annual risk of tuberculosis infection in rural China: a population-based prospective study
AID  - 10.1183/13993003.00235-2016
DP  - 2016 Jul 01
TA  - European Respiratory Journal
PG  - 168--178
VI  - 48
IP  - 1
4099  - http://erj.ersjournals.com/content/48/1/168.short
4100  - http://erj.ersjournals.com/content/48/1/168.full
SO  - Eur Respir J2016 Jul 01; 48
AB  - Prospective population data on the incidence of tuberculosis (TB) infection has been sparsely reported in the global literature.A population-based prospective study was conducted in rural China to investigate the annual risk of TB infection, and its persistence using serial tuberculin skin tests (TSTs) and an interferon-γ release assay. In total, 13 580 eligible participants from four rural sites, identified as TST negative (<10 mm) or QuantiFERON-TB Gold In-Tube (QFT) (an interferon-γ release assay) negative from a baseline survey, were included in the first year's follow-up examination.The annual conversion rate of QFT among the study sites ranged between 2.1% and 4.9% (average 3.1%), and the incidence of TST conversion ranged between 6.0% and 31.1% (average 14.5%). During the second year's follow-up, infection persistence was investigated using 390 subjects with QFT conversions. Among them, 49.7% (164 out of 330) were found to be consistently QFT positive. Both the conversion and the persistence of QFT positivity were found to be significantly increased with increasing age.In conclusion, the annual TB infection rate was suggested to be ∼1.5% based on persistent positive results after QFT conversion in rural China. Therefore, infection control among those high-risk populations, including the elderly, should be prioritised for TB control in China.Annual TB infection rate ∼1.5% in rural China, based on persistent positive results after IGRA conversion http://ow.ly/4n95Cw