PT  - JOURNAL ARTICLE
AU  - Michele Mondoni
AU  - Giovanni Sotgiu
AU  - Martina Bonifazi
AU  - Simone Dore
AU  - Elena Maria Parazzini
AU  - Paolo Carlucci
AU  - Stefano Gasparini
AU  - Stefano Centanni
TI  - Transbronchial needle aspiration in peripheral pulmonary lesions: a systematic review and meta-analysis
AID  - 10.1183/13993003.00051-2016
DP  - 2016 Jul 01
TA  - European Respiratory Journal
PG  - 196--204
VI  - 48
IP  - 1
4099  - http://erj.ersjournals.com/content/48/1/196.short
4100  - http://erj.ersjournals.com/content/48/1/196.full
SO  - Eur Respir J2016 Jul 01; 48
AB  - Fluoroscopy-guided transbronchial needle aspiration (TBNA) has long been used in the diagnosis of peripheral pulmonary lesions (PPLs), although its diagnostic performance varies considerably.We conducted a systematic review and meta-analysis evaluating the accuracy of TBNA in the diagnosis of PPLs, comparing its diagnostic yield with transbronchial biopsy (TBB) and assessing the main predictors of a successful aspirate.In 18 studies, the overall TBNA yield was 0.53 (95% CI 0.44–0.61). TBNA showed a higher accuracy when directly compared to TBB (0.60 (95% CI 0.49–0.71) versus 0.45 (95% CI 0.37–0.54)). The subgroup analyses documented a higher TBNA yield when the computed tomography (CT) bronchus sign was present (0.70 (95% CI 0.63–0.77) versus 0.51 (95% CI 0.38–0.64)), when rapid on-site evaluation (ROSE) was performed (0.62 (95% CI 0.43–0.79) versus 0.51 (95% CI 0.42–0.60)), in the case of malignant lesions (0.55 (95% CI 0.44–0.66) versus 0.17 (95% CI 0.11–0.24)) and for lesions >3 cm (0.81 (95% CI 0.73–0.87) versus 0.55 (95% CI 0.47–0.63)).Conventional TBNA is a useful sampling technique for the diagnosis of PPL, with a higher diagnostic yield than TBB. The presence of CT bronchus sign, an underlying malignant process, lesion size >3 cm and ROSE employment are predictors of a higher yield.Fluoroscopy-guided transbronchial needle aspiration is a useful technique in diagnosing peripheral pulmonary lesions http://ow.ly/4mK0sB