RT Journal Article SR Electronic T1 “Scar-cinoma”: viewing the fibrotic lung mesenchymal cell in the context of cancer biology JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1842 OP 1854 DO 10.1183/13993003.01201-2015 VO 47 IS 6 A1 Jeffrey C. Horowitz A1 John J. Osterholzer A1 Antonia Marazioti A1 Georgios T. Stathopoulos YR 2016 UL http://erj.ersjournals.com/content/47/6/1842.abstract AB Lung cancer and pulmonary fibrosis are common, yet distinct, pathological processes that represent urgent unmet medical needs. Striking clinical and mechanistic parallels exist between these distinct disease entities. The goal of this article is to examine lung fibrosis from the perspective of cancer-associated phenotypic hallmarks, to discuss areas of mechanistic overlap and distinction, and to highlight profibrotic mechanisms that contribute to carcinogenesis. Ultimately, we speculate that such comparisons might identify opportunities to leverage our current understanding of the pathobiology of each disease process in order to advance novel therapeutic approaches for both. We anticipate that such “outside the box” concepts could be translated to a more precise and individualised approach to fibrotic diseases of the lung.Lung fibrosis and cancer are distinct, but share a number of cell signalling and phenotypic features http://ow.ly/Za9YB