TY - JOUR T1 - Real-life assessment of the multidimensional nature of dyspnoea in COPD outpatients JF - European Respiratory Journal JO - Eur Respir J SP - 1668 LP - 1679 DO - 10.1183/13993003.01998-2015 VL - 47 IS - 6 AU - Capucine Morélot-Panzini AU - Hélène Gilet AU - Bernard Aguilaniu AU - Philippe Devillier AU - Alain Didier AU - Thierry Perez AU - Christophe Pignier AU - Benoit Arnould AU - Thomas Similowski Y1 - 2016/06/01 UR - http://erj.ersjournals.com/content/47/6/1668.abstract N2 - Dyspnoea is a prominent symptom of chronic obstructive pulmonary disease (COPD). Recent multidimensional dyspnoea questionnaires like the Multidimensional Dyspnea Profile (MDP) individualise the sensory and affective dimensions of dyspnoea. We tested the MDP in COPD outpatients based on the hypothesis that the importance of the affective dimension of dyspnoea would vary according to clinical characteristics.A multicentre, prospective, observational, real-life study was conducted in 276 patients. MDP data were compared across various categories of patients (modified Medical Research Council (mMRC) dyspnoea score, COPD Assessment Test (CAT) score, Global Initiative for Chronic Obstructive Lung Disease (GOLD) airflow obstruction categories, GOLD “ABCD” categories, and Hospital Anxiety and Depression Scale (HADS)). Univariate and multivariate regressions were conducted to explore factors influencing the affective dimension of dyspnoea. Cluster analysis was conducted to create homogeneous patient profiles.The MDP identified a more marked affective dimension of dyspnoea with more severe mMRC, CAT, 12-item Short-Form Health Survey mental component, airflow obstruction and HADS. Multivariate analysis identified airflow obstruction, depressive symptoms and physical activity as determinants of the affective dimension of dyspnoea. Patients clustered into an “elderly, ex-smoker, severe disease, no rehabilitation” group exhibited the most marked affective dimension of dyspnoea.An affective/emotional dimension of dyspnoea can be identified in routine clinical practice. It can contribute to the phenotypic description of patients. Studies are needed to determine whether targeted therapeutic interventions can be designed and whether they are useful.The affective dimension of dyspnoea can be assessed in COPD outpatients and could help personalise treatment http://ow.ly/YHRiW ER -