RT Journal Article
SR Electronic
T1 Pulmonary rehabilitation in lymphangioleiomyomatosis: a controlled clinical trial
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1452
OP 1460
DO 10.1183/13993003.01683-2015
VO 47
IS 5
A1 Mariana S. Araujo
A1 Bruno G. Baldi
A1 Carolina S.G. Freitas
A1 André L.P. Albuquerque
A1 Cibele C.B. Marques da Silva
A1 Ronaldo A. Kairalla
A1 Celso R.F. Carvalho
A1 Carlos R.R. Carvalho
YR 2016
UL http://erj.ersjournals.com/content/47/5/1452.abstract
AB Lymphangioleiomyomatosis (LAM) is a cystic lung disease frequently associated with reduced exercise capacity. The aim of this study was to assess safety and efficacy of pulmonary rehabilitation in LAM.This controlled clinical trial included 40 patients with LAM and a low physical activity level. The pulmonary rehabilitation programme comprised 24 aerobic and muscle strength training sessions and education. The primary outcome was exercise capacity (endurance time during a constant work rate exercise test). Secondary outcomes included health-related quality of life (St George's Respiratory Questionnaire (SGRQ)), 6-min walking distance (6MWD), dyspnoea, peak oxygen consumption (V′O2), daily physical activity (pedometer), symptoms of anxiety and depression, lung function and peripheral muscle strength (one-repetition maximum).The baseline characteristics were well balanced between the groups. The pulmonary rehabilitation group exhibited improvements in the following outcomes versus controls: endurance time (median (interquartile range) 169 (2–303) s versus −33 (−129–39) s; p=0.001), SGRQ (median (interquartile range) −8 (−16–2) versus 2 (−4–5); p=0.002) and 6MWD (median (interquartile range) 59 (13–81) m versus 20 (−12–30) m; p=0.002). Dyspnoea, peak V′O2, daily physical activity and muscle strength also improved significantly. No serious adverse events were observed.Pulmonary rehabilitation is a safe intervention and improves exercise capacity, dyspnoea, daily physical activity, quality of life and muscle strength in LAM.Evaluation of a pulmonary rehabilitation programme in lymphangioleiomyomatosis demonstrates safety and efficacy http://ow.ly/Xmofp