RT Journal Article
SR Electronic
T1 The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP ERJ-01016-2015
DO 10.1183/13993003.01016-2015
A1 C.I. Vardavas
A1 C. Hohmann
A1 E. Patelarou
A1 D. Martinez
A1 A.J. Henderson
A1 R. Granell
A1 J. Sunyer
A1 M. Torrent
A1 M.P. Fantini
A1 D. Gori
A1 I. Annesi-Maesano
A1 R. Slama
A1 L. Duijts
A1 J.C. de Jongste
A1 J.J. Aurrekoetxea
A1 M. Basterrechea
A1 E. Morales
A1 F. Ballester
A1 M. Murcia
A1 C. Thijs
A1 M. Mommers
A1 C.E. Kuehni
A1 E.A. Gaillard
A1 C. Tischer
A1 J. Heinrich
A1 C. Pizzi
A1 D. Zugna
A1 U. Gehring
A1 A. Wijga
A1 L. Chatzi
A1 M. Vassilaki
A1 A. Bergström
A1 E. Eller
A1 S. Lau
A1 T. Keil
A1 M. Nieuwenhuijsen
A1 M. Kogevinas
YR 2016
UL http://erj.ersjournals.com/content/early/2016/03/10/13993003.01016-2015.abstract
AB Maternal smoking during pregnancy increases childhood asthma risk, but health effects in children of nonsmoking mothers passively exposed to tobacco smoke during pregnancy are unclear. We examined the association of maternal passive smoking during pregnancy and wheeze in children aged ≤2 years.Individual data of 27 993 mother–child pairs from 15 European birth cohorts were combined in pooled analyses taking into consideration potential confounders.Children with maternal exposure to passive smoking during pregnancy and no other smoking exposure were more likely to develop wheeze up to the age of 2 years (OR 1.11, 95% CI 1.03–1.20) compared with unexposed children. Risk of wheeze was further increased by children's postnatal passive smoke exposure in addition to their mothers' passive exposure during pregnancy (OR 1.29, 95% CI 1.19–1.40) and highest in children with both sources of passive exposure and mothers who smoked actively during pregnancy (OR 1.73, 95% CI 1.59–1.88). Risk of wheeze associated with tobacco smoke exposure was higher in children with an allergic versus nonallergic family history.Maternal passive smoking exposure during pregnancy is an independent risk factor for wheeze in children up to the age of 2 years. Pregnant females should avoid active and passive exposure to tobacco smoke for the benefit of their children's health.Prenatal and postnatal exposure to active and passive smoking independently increase early wheeze risk in children http://ow.ly/XZvQQ