TY - JOUR T1 - Paradoxical decrease in isoprostane and increase in superoxide dismutase following CPAP withdrawal in OSA JF - European Respiratory Journal JO - Eur Respir J SP - 1014 LP - 1015 DO - 10.1183/13993003.01725-2015 VL - 47 IS - 3 AU - Charalambos Antoniades AU - Regent Lee AU - Malcolm Kohler AU - John Stradling Y1 - 2016/03/01 UR - http://erj.ersjournals.com/content/47/3/1014.abstract N2 - We thank Monneret and Bonnefont-Rousselot for their commentary. Our controlled trial design overcomes most of their concerns; any failure of assay techniques would not have produced a biased result, but in fact would have decreased the chances of finding any between-group effects. In our study we observed a statistically significant decrease in urinary F2-isoprostanes following the withdrawal of continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnoea (OSA), in a randomised, 2-week trial, where those involved in the assays were entirely blind to group allocation [1]. In addition to this unexpected result, we observed no significant change in any plasma marker of oxidative stress we measured in this population (malondialdehyde and lipid hydroperoxides) or even the production of superoxide radicals by peripheral blood mononuclear cells. It is important to note that these were morning measurements.Paradoxical decrease in isoprostane and increase in superoxide dismutase following CPAP withdrawal in OSA http://ow.ly/UcgYP ER -