RT Journal Article
SR Electronic
T1 Social inequalities in wheezing in children: findings from the UK Millennium Cohort Study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 818
OP 828
DO 10.1183/13993003.01117-2015
VO 47
IS 3
A1 David C. Taylor-Robinson
A1 Anna Pearce
A1 Margaret Whitehead
A1 Rosalind Smyth
A1 Catherine Law
YR 2016
UL http://erj.ersjournals.com/content/47/3/818.abstract
AB Wheezing in childhood is socially patterned, but it is unclear what factors explain the social differences.Regression analysis of the UK Millennium Cohort Study, based on 11 141 singleton children who participated at ages 9 months and 3, 5 and 7 years. Relative risk ratios (RRR) for early and persistent/relapsing wheeze were estimated using multinomial regression, according to measures of socioeconomic circumstances. Maternal, antenatal and early-life characteristics were assessed as potential mediators.Children of mothers with no educational qualifications were more likely to have both wheeze types, compared to children of mothers with degree-level qualifications (RRR 1.53, 95% CI 1.26–1.86 for early wheeze; 1.32 95% CI 1.04–1.67 for persistent/relapsing wheeze). Controlling for maternal age, smoking during pregnancy and breastfeeding removed the elevated risk of wheezing. Male sex, maternal age, body mass index, atopy, smoking during pregnancy, preterm birth, breastfeeding, exposure to other children and furry pets were independently associated with wheezing, but the pattern of association varied between wheezing types.In this representative UK cohort, adjustment for maternal smoking during pregnancy and breastfeeding removed the socioeconomic inequalities in common wheezing phenotypes. Policies to reduce the social gradient in these risk factors may reduce inequalities in wheezing and asthma.Increased wheeze in disadvantaged children removed by adjusting for smoking in pregnancy and lower breastfeeding rate http://ow.ly/TLLD8