RT Journal Article
SR Electronic
T1 Pulmonary artery size as a predictor of outcomes in idiopathic pulmonary fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP ERJ-01532-2015
DO 10.1183/13993003.01532-2015
A1 Stephanie Shin
A1 Christopher S. King
A1 Nitin Puri
A1 Oksana A. Shlobin
A1 A. Whitney Brown
A1 Shahzad Ahmad
A1 Nargues A. Weir
A1 Steven D. Nathan
YR 2016
UL http://erj.ersjournals.com/content/early/2016/02/04/13993003.01532-2015.abstract
AB IPF patients have heightened propensity for pulmonary hypertension, which portends a worse outcome. Presence of pulmonary hypertension may be reflected in an enlarged pulmonary artery. We investigated pulmonary artery size measured on high-resolution computed tomography (HRCT) as an outcome predictor in IPF.We retrospectively reviewed all IPF patients evaluated at a tertiary-care centre between 2008 and 2013. Pulmonary artery and ascending aorta diameters were measured from chest HRCT with pulmonary artery:ascending aorta diameter (PA:A) ratio calculations. Outcome analysis defined by either death or lung transplant based on pulmonary artery size and PA:A ratio over 60 months was performed. Independent effects of different variables on overall outcomes were evaluated using the Cox proportional hazards model.98 IPF patients with available HRCT scans had a mean pulmonary artery diameter and PA:A ratio of 32.8 mm and 0.94, respectively. Patients with a PA:A ratio >1 had higher risk of death or transplant compared with a PA:A ratio ≤1 (p<0.001). A PA:A ratio >1 was also an independent predictor of outcomes in unadjusted and adjusted outcomes analyses (hazard ratio 3.99, p<0.001 and hazard ratio 3.35, p=0.002, respectively).A PA:A ratio >1 is associated with worse outcomes in patients with IPF. HRCT PA:A ratio measurement may assist in risk stratification and prognostication of IPF patients.Pulmonary artery measurements on imaging can be utilised for risk stratification and prognostication in IPF http://ow.ly/WNO2h