RT Journal Article
SR Electronic
T1 Treatable traits: toward precision medicine of chronic airway diseases
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 410
OP 419
DO 10.1183/13993003.01359-2015
VO 47
IS 2
A1 Agusti, Alvar
A1 Bel, Elisabeth
A1 Thomas, Mike
A1 Vogelmeier, Claus
A1 Brusselle, Guy
A1 Holgate, Stephen
A1 Humbert, Marc
A1 Jones, Paul
A1 Gibson, Peter G.
A1 Vestbo, Jørgen
A1 Beasley, Richard
A1 Pavord, Ian D.
YR 2016
UL http://erj.ersjournals.com/content/47/2/410.abstract
AB Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms (i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed (i.e. phenotypes) which require individualised treatment. Precision medicine is defined as “treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations”. In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular.A discussion of the concept of “treatable traits” as a way towards precision medicine of chronic airway diseases http://ow.ly/UbJAm