RT Journal Article
SR Electronic
T1 Sex-specific features of emphysema among current and former smokers with COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 104
OP 112
DO 10.1183/13993003.00996-2015
VO 47
IS 1
A1 Megan Hardin
A1 Marilyn Foreman
A1 Mark T. Dransfield
A1 Nadia Hansel
A1 MeiLan K. Han
A1 Michael H. Cho
A1 Surya P. Bhatt
A1 Joe Ramsdell
A1 David Lynch
A1 Jeffrey L. Curtis
A1 Edwin K. Silverman
A1 George Washko
A1 Dawn DeMeo
YR 2016
UL http://erj.ersjournals.com/content/47/1/104.abstract
AB Recent studies suggest that males with chronic obstructive pulmonary disease (COPD) have more emphysema than females. It is not known if these differences persist across degrees of COPD severity. Our aim was to identify sex-specific differences in quantitative emphysema within COPD subgroups based on COPD severity.We included non-Hispanic white and African-American subjects from the COPDGene study with at least 10 pack-years of smoking and COPD Global Initiative for Chronic Obstructive Lung Disease (GOLD) spirometry grade II or greater. We examined sex-specific differences in log-transformed emphysema (log per cent low-attenuation area (%LAA)) by GOLD spirometry grade among subjects with early-onset COPD (<55 years old) and advanced emphysema (>25% emphysema).Compared with females, males had higher log %LAA: overall (1.97±1.4 versus 1.69±1.6, β=0.32 (0.04), p=1.34×10−14), and among non-Hispanic white (p=8.37×10−14) and African-American subjects (p=0.002). Females with early-onset COPD, severe emphysema and GOLD grade IV COPD had similar emphysema as males, but markedly fewer pack-years smoking (early-onset, p=0.01; severe emphysema and GOLD grade IV, p<0.001).This study identifies subsets of female smokers with COPD who are particularly susceptible to parenchymal destruction.In severe COPD subgroups, females have greater susceptibility to smoking-related parenchymal lung damage/emphysema http://ow.ly/Stqyz