TY - JOUR T1 - Primary tumour standardised uptake value is prognostic in nonsmall cell lung cancer: a multivariate pooled analysis of individual data JF - European Respiratory Journal JO - Eur Respir J SP - 1751 LP - 1761 DO - 10.1183/13993003.00099-2015 VL - 46 IS - 6 AU - Marianne Paesmans AU - Camilo Garcia AU - Ching-Yee Oliver Wong AU - Edward F. Patz, Jr AU - Ritsuko Komaki AU - Susanne Eschmann AU - Ramaswamy Govindan AU - Johan Vansteenkiste AU - Anne-Pascale Meert AU - Wouter K. de Jong AU - Nasser Khaled Altorki AU - Kotaro Higashi AU - Angela Van Baardwijk AU - Gerben R. Borst AU - Lieveke Ameye AU - Jean-Jacques Lafitte AU - Thierry Berghmans AU - Patrick Flamen AU - Ramon Rami-Porta AU - Jean-Paul Sculier Y1 - 2015/12/01 UR - http://erj.ersjournals.com/content/46/6/1751.abstract N2 - 18F-fluoro-2-deoxy-d-glucose positron emission tomography (PET) complements conventional imaging for diagnosing and staging lung cancer. Two literature-based meta-analyses suggest that maximum standardised uptake value (SUVmax) on PET has univariate prognostic value in nonsmall cell lung cancer (NSCLC). We analysed individual data pooled from 12 studies to assess the independent prognostic value of binary SUVmax for overall survival.After searching the published literature and identifying unpublished data, study coordinators were contacted and requested to provide data on individual patients. Cox regression models stratified for study were used.Data were collected for 1526 patients (median age 64 years, 60% male, 34% squamous cell carcinoma, 47% adenocarcinoma, 58% stage I–II). The combined univariate hazard ratio for SUVmax was 1.43 (95% CI 1.22–1.66) and nearly identical if the SUV threshold was calculated stratifying for histology. Multivariate analysis of patients with stage I–III disease identified age, stage, tumour size and receipt of surgery as independent prognostic factors; adding SUV (HR 1.58, 95% CI 1.27–1.96) improved the model significantly. The only detected interaction was between SUV and stage IV disease.SUV seems to have independent prognostic value in stage I–III NSCLC, for squamous cell carcinoma and for adenocarcinoma.SUV has independent prognostic value in stage I–III NSCLC, both for squamous cell carcinoma and for adenocarcinoma http://ow.ly/Q2FKI ER -