RT Journal Article
SR Electronic
T1 High D-dimer levels after stopping anticoagulants in pulmonary embolism with sleep apnoea
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1691
OP 1700
DO 10.1183/13993003.02041-2014
VO 46
IS 6
A1 Angela García Suquia
A1 Alberto Alonso-Fernández
A1 Mónica de la Peña
A1 David Romero
A1 Javier Piérola
A1 Miguel Carrera
A1 Antonia Barceló
A1 Joan B. Soriano
A1 Meritxell Arque
A1 Carmen Fernández-Capitán
A1 Alicia Lorenzo
A1 Francisco García-Río
YR 2015
UL http://erj.ersjournals.com/content/46/6/1691.abstract
AB Obstructive sleep apnoea is a risk factor for pulmonary embolism. Elevated D-dimer levels and other biomarkers are associated with recurrent pulmonary embolism. The objectives were to compare the frequency of elevated D-dimer levels (>500 ng·mL−1) and further coagulation biomarkers after oral anticoagulation withdrawal in pulmonary embolism patients, with and without obstructive sleep apnoea, including two control groups without pulmonary embolism.We performed home respiratory polygraphy. We also measured basic biochemical profile and haemogram, and coagulation biomarkers (D-dimer, prothrombin fragment 1+2, thrombin-antithrombin complex, plasminogen activator inhibitor 1, and soluble P-selectin).64 (74.4%) of the pulmonary embolism cases and 41 (46.11%) of the controls without pulmonary embolism had obstructive sleep apnoea. Plasmatic D-dimer was higher in PE patients with OSA than in those without obstructive sleep apnoea. D-dimer levels were significantly correlated with apnoea–hypopnoea index, and nocturnal hypoxia. There were more patients with high D-dimer after stopping anticoagulants in those with pulmonary embolism and obstructive sleep apnoea compared with PE without obstructive sleep apnoea (35.4% versus 19.0%, p=0.003). Apnoea–hypopnoea index was independently associated with high D-dimer.Pulmonary embolism patients with obstructive sleep apnoea had higher rates of elevated D-dimer levels after anticoagulation discontinuation for pulmonary embolism than in patients without obstructive sleep apnoea and, therefore, higher procoagulant state that might increase the risk of pulmonary embolism recurrence.Pulmonary embolism patients with sleep apnoea are more likely to have elevated post-anticoagulation plasma D-dimer http://ow.ly/NHoiu