RT Journal Article SR Electronic T1 Differential response to pulmonary rehabilitation in COPD: multidimensional profiling JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1625 OP 1635 DO 10.1183/13993003.00350-2015 VO 46 IS 6 A1 Martijn A. Spruit A1 Ingrid M.L. Augustin A1 Lowie E. Vanfleteren A1 Daisy J.A. Janssen A1 Swetlana Gaffron A1 Herman-Jan Pennings A1 Frank Smeenk A1 Willem Pieters A1 Jan J.A.M. van den Bergh A1 Arent-Jan Michels A1 Miriam T.J. Groenen A1 Erica P.A. Rutten A1 Emiel F.M. Wouters A1 Frits M.E. Franssen YR 2015 UL http://erj.ersjournals.com/content/46/6/1625.abstract AB The aim of the present study was to profile a multidimensional response to pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD).Dyspnoea, exercise performance, health status, mood status and problematic activities of daily life were assessed before and after a 40-session pulmonary rehabilitation programme in 2068 patients with COPD (mean forced expiratory volume in 1 s of 49% predicted). Patients were ordered by their overall similarity concerning their multidimensional response profile, which comprises the overall response on MRC dyspnoea grade, 6MWD, cycle endurance time, Canadian Occupational Performance Measure performance and satisfaction scores, Hospital Anxiety and Depression Scale anxiety and depression, and St George's Respiratory Questionnaire total score, using a novel non-parametric regression technique.Patients were clustered into four groups with distinct multidimensional response profiles: n=378 (18.3%; “very good responder”), n=742 (35.9%; “good responder”), n=731 (35.4%; “moderate responder”), and n=217 (10.5%; “poor responder”). Patients in the “very good responder” cluster had higher symptoms of dyspnoea, number of hospitalisations <12 months, worse exercise performance, worse performance and satisfaction scores for problematic activities of daily life, more symptoms of anxiety and depression, worse health status, and a higher proportion of patients following an inpatient PR programme compared to the other three clusters.A multidimensional response outcome needs to be considered to study the efficacy of pulmonary rehabilitation services in patients with COPD, as responses to regular outcomes are differential within patients with COPD.Efficacy of pulmonary rehabilitation in patients with COPD needs to be assessed using a multidimensional response http://ow.ly/RsfYK