PT  - JOURNAL ARTICLE
AU  - Tatiana Martynenko
AU  - Irina Balatskaya
AU  - Olga Dunaeva
AU  - Andrey Momot
AU  - Yakov Shoychet
TI  - Endothelial dysfunction and prognostic significance of endothelin-1 in patients with severe pneumonia and pulmonary sepsis
AID  - 10.1183/13993003.congress-2015.PA2637
DP  - 2015 Sep 01
TA  - European Respiratory Journal
PG  - PA2637
VI  - 46
IP  - suppl 59
4099  - http://erj.ersjournals.com/content/46/suppl_59/PA2637.short
4100  - http://erj.ersjournals.com/content/46/suppl_59/PA2637.full
SO  - Eur Respir J2015 Sep 01; 46
AB  - Background: According to our data, severe pneumonia (SP) occurs with severe sepsis (PS) in 92.9% of patients, of them - 26.6% with septic shock, 7.1% of patients with sepsis.Objective: Monitoring of endothelin-1 (E-1) changes as an indicator of endothelial dysfunction and a sepsis marker, determining its prognostic significance in SP with PS.Methods: We have studied the concentration of E-1 in the blood of 68 patients with SP and PS at 1, 3-5 and 7-10 days of hospitalization. Died - 10 (14.7%) patients (comparison group), survived - 58 (85.3%) patients (the main group). The control group - 26 people.Results: The obtained results are shown in figure 1 By regression analysis we have determined the value of the negative trend (increasing) the level of E-1 at 7-10 days of hospitalization (OR-9,4; p = 0,045) as a predictor of mortality in SP with PS.Conclusion: The increase of E-1 was determined in all patients with SP, to a greater degree in patients with adverse outcome. In the surviving patients with SP and PS at 7-10 day level of E-1 decreased and did not differ from the control, in contrast, in the group of deceased E-1 has increased steadily at 3-5 and 7-10 days compared with baseline values. The data obtained indicate the progression of severe systemic endotheliosisat 7-10 days in patients with SP with fatal outcome, which is a poor prognostic factor in SP with PS.