@article {BartoliOA2923, author = {Maria Laura Bartoli and Dario Nieri and Sandra Antonelli and Francesco Costa and Gianna Decusatis and Claudia De Simone and Laura Malagrin{\`o} and Sabrina Santerini and Barbara Vagaggini and Pierluigi Paggiaro}, title = {2011 GOLD categories may identify different copd phenotypes}, volume = {46}, number = {suppl 59}, elocation-id = {OA2923}, year = {2015}, doi = {10.1183/13993003.congress-2015.OA2923}, publisher = {European Respiratory Society}, abstract = {Aim: The physiological and biological features of new 2011 GOLD (Global Initiative for Chronic Obstructive Lung Disease) categories are not well described (Agusti A et al. Eur Respir J 2013;42:636-46).Methods: We analyzed 74 patients with COPD (63 males, age 70{\textpm}8 years, 55 ex-smokers, post-bronc FEV1\% 51.8{\textpm}19.6 \%pred) who attended to a pulmonary rehabilitation program. All patients, in a stable phase of the disease, underwent complete clinical and functional assessment and sputum induction for differential cell count. Regular treatment was withdrew 24 hours before examination; none was under regular oral corticosteroid. According to 2011 GOLD Guidelines, patients were stratified in four A, B, C, D categories.Results: Main differences between the four groups are reported in the table.GOLD 2011 categoriesABCDp valuePatients, N 7413 (18\%)5 (7\%)20 (27\%)36 (48\%)TLC, \%105.4{\textpm}9.4131.7{\textpm}16.0120.6{\textpm}24.8131.4{\textpm}30.3= 0.02DLCO, \%86.3{\textpm}16.353.6{\textpm}19.591.3{\textpm}27.653.7{\textpm}19.7\<0.0001Neutrophils, \%66.5 (38-91)74.9 (71-96)72.1 (18-88)78.8 (58-97)= 0.03Eosinophils, \%2.4 (0.4-21)1.4 (0-3.5)2.9 (0-60)0.9 (0-23)= 0.02mean{\textpm}SD; sputum cells: median (range)TableGroups A and C show better quality of life (by Saint George Respiratory Questionnaire) and higher sputum eosinophils, while groups B and D had higher TLC, lower DLCO and higher sputum neutrophils.Conclusion: 2011 GOLD categories may identify different COPD phenotypes (prominent chronic bronchitis vs emphysema).}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/46/suppl_59/OA2923}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }