TY - JOUR T1 - Endoscopic lung volume reduction with nitinol coils in very severe emphysema: Mid-term effectiveness vs. disease related continuous loss of lung function JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA804 VL - 46 IS - suppl 59 SP - PA804 AU - Mathias Jüch AU - Hans Jost Achenbach Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA804.abstract N2 - Background: Bilateral endoscopic lung volume reduction with nitinol coils (PneumRx Inc., USA) in severe emphysema has been shown to improve exercise capacity, lung function, and quality of life. We present data from 30 bilaterally treated patients showing a fading benefit in sequential mid-term follow-up (f/u).Methods: 30 patients with COPD GOLD III/IV, category D and heterogenous or homogenous emphysema (mean RV 253±54%, mean FEV1 29,5±5,7%, mean 6MWD 299±108m, mean CAT 24,7±7 pts.) underwent bilateral LVRC. F/u including lung function, exercise capacity and quality of life was conducted 30 to 90, 91 to 180, 181 to 270 and more than 270 days post-treatment.Results: Overall, patients showed an improvement in all measured parameters in sequential f/u. The most significant effects were detected 30 to 90 days post-treatment: mean RV -620±890 ml, mean FEV1+90±190 ml, mean 6MWD +45±69m, mean CAT score -6,8±6 pts.). Day 91 to 180: mean RV -460±760 ml, mean FEV1+20±110 ml, mean 6MWD +24±68m, mean CAT score -3,7±5 pts. Day 181 to 270: mean RV -570±490 ml, mean FEV1+20±140 ml, mean 6MWD -18,5±64m, mean CAT score -3,2±8 pts. More than 270 days (mean 385 days): mean RV -510±760 ml, mean FEV1+20±110 ml, mean 6MWD +21,8±70m, mean CAT score -2,0±7 pts. Updated f/u data will be presented at the ERS congress.Conclusions: Coil treatment leads to improvement of exercise capacity, lung function, and quality of life in mid-term f/u. The effects seemed to diminish over time, although patients still showed significant benefit at > 270 days post-treatment. An explanation might be disease progression despite the positive effects of coil treatment. ER -