PT  - JOURNAL ARTICLE
AU  - Nathalia Navi
AU  - Clarissa Laia Franco
AU  - Ana Letícia Ferreira Pinto
AU  - Caio Cesxar Vasconcellos
AU  - Ludmila Santos
AU  - Teresa Sarmet
AU  - Selma Sias
TI  - Study of post-infectious bronchiolitis obliterans in children
AID  - 10.1183/13993003.congress-2015.PA1325
DP  - 2015 Sep 01
TA  - European Respiratory Journal
PG  - PA1325
VI  - 46
IP  - suppl 59
4099  - http://erj.ersjournals.com/content/46/suppl_59/PA1325.short
4100  - http://erj.ersjournals.com/content/46/suppl_59/PA1325.full
SO  - Eur Respir J2015 Sep 01; 46
AB  - Introduction: Bronchiolitis obliterans is a severe and uncommon form of chronic obstructive pulmonary disease.Objective: To analyze clinical manifestations, tomography, cintilography and functional characteristics of children with post-infectious bronchiolitis obliterans at the University Hospital Antonio Pedro, Niterói, RJ, Brazil.Results: We studied 12 children that remained with tachypnea and respiratory symptoms (75%), wheezing (83.3%) and cough (75%) after the initial onset of acute viral bronchiolitis. The mean age was 19.7 months, and there was a predominance of males (91.66%). The risk factors were prolonged hospitalization (mean = 35.1 days) and oxygen therapy (50% in mechanical ventilation and 50% in macronebulization). Symptoms include wheezing, and tachypnea (100%), cough (75%), dyspnea (66.6%), snoring (33.3%) and deficit in weight gain and crackles. Atelectasis, peribronchial thickening and mosaic pattern were the main CT alterations. Of the five children who underwent pulmonary scintigraphic only one was normal. There was a significant correlation (p <0.05) between the clinical score and the scintigraphic score. Lung function in five children showed severe obstructive pattern.Conclusions: There is no need lung biopsy for diagnosis of this disease. It can be achieved through a history of acute viral infection requiring hospital admission and oxygen therapy, associated with airway obstruction detected on physical examination and / or pulmonary function test six weeks after the initial event, tomographic image suggestive of chronic obstructive disease and exclusion of other chronic obstructive lung diseases. Scintigraphy is an important tool for assessing the severity and presence of pulmonary sequel.