RT Journal Article
SR Electronic
T1 Exhaled endogenous particles in a general population sample enriched with asthma subjects
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA2090
DO 10.1183/13993003.congress-2015.PA2090
VO 46
IS suppl 59
A1 Lärstad, Mona
A1 Mirgorodskaya, Ekaterina
A1 Holm, Mathias
A1 Koca, Hatice
A1 Viklund, Emilia
A1 Torén, Kjell
A1 Bake, Björn
A1 Olin, Anna-Carin
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA2090.abstract
AB Introduction: Exhaled particles are formed in the small airways during airway re-opening after airway closure. Sampling and analysis of particles give the opportunity of measuring biomarkers noninvasively. Our aims were to investigate if biomarker concentrations (particle number, surfactant protein A (SP-A) and albumin) are influenced by sex, anthropometry and lung function, and to see if subjects with asthma differ from healthy subjects.Methods: Subjects comprised of a general population sample (n=199) enriched with subjects with asthma (n=37) recruited from the European Respiratory Community Survey during 2011 and 2012, of which n=121 were healthy subjects. Repeated breath manoeuvres were performed and particles were counted and collected using the PExA® technique. ELISA kits were used for quantification of SP-A and albumin. Spearman rank correlations were used to test for linear relationships. Groups were compared using a nonparametric test.Results: Healthy females and males exhaled similar number of particles in each exhalation, but females exhaled significantly more particles (p=0.005) when expressed as particles per litre exhaled air. There was a correlation (p<0.0001) between particles per exhalation and FEV1 (% pred). Number of exhaled particles increased with higher age. Regarding asthma, there was a correlation (p=0.02) between particles per exhalation and FEV1 (% pred). Increased bronchomotor tone was associated with decreased number of exhaled particles. There were no difference in SP-A and albumin concentrations between groups.Conclusions: Number of exhaled particles seems to be associated with lung function, and could be a promising non-invasive biomarker.