PT  - JOURNAL ARTICLE
AU  - Wim Vos
AU  - Cedric Van Holsbeke
AU  - Wouter Van Geffen
AU  - Huib Kerstjens
AU  - Massimo Pistolesi
AU  - Omar Usmani
AU  - Bita Hajian
AU  - Anthony Cahn
AU  - Jan De Backer
AU  - Wilfried De Backer
TI  - Changes in functional respiratory imaging (FRI) endpoints correlate with changes in patient reported outcomes (PRO) after recovering from acute COPD exacerbation
AID  - 10.1183/13993003.congress-2015.OA2948
DP  - 2015 Sep 01
TA  - European Respiratory Journal
PG  - OA2948
VI  - 46
IP  - suppl 59
4099  - http://erj.ersjournals.com/content/46/suppl_59/OA2948.short
4100  - http://erj.ersjournals.com/content/46/suppl_59/OA2948.full
SO  - Eur Respir J2015 Sep 01; 46
AB  - Although COPD exacerbations are an accepted endpoint in clinical trials, episodes of exacerbation remain a poorly understood phenomenon.Aims: We aim to increase our understanding of the pathophysiology of COPD exacerbations using HRCT-based FRI and to explore the relationship with PROs.Methods: 50 COPD patients were studied during an episode of acute exacerbation. FRI endpoints, PFT parameters and PRO measures were obtained during the episode and 6-8 weeks after recovery.Results: We observed that changes in FRI based airway resistance (iRaw) measured at FRC were significantly correlated with changes in SGRQ Total (R=0.37, p=0.016), SGRQ Activity (R=0.49, p=0.001, figure 1), SGRQ Symptoms (R=0.4, p=0.009), CAT (R=0.32, p=0.042) and mMRC (R=0.39, p=0.012). Changes in FRI based specific airway volume (siVaw) measured at FRC was significantly correlated with the changes in SGRQ Total (R=0.36, p=0.019), SGRQ Activity (R=0.48, p=0.001), SGRQ Symptoms (R=0.45, p=0.002), CAT (R=0.39, p=0.011) and mMRC (R=0.37, p=0.014). In this cohort changes in FEV1 correlated significantly with changes in SGRQ Activity (R=0.32, p=0.037) and in CAT (R=0.37, p=0.01) and mMRC (R=0.32, p=0.035).Conclusions: Changes in FRI based airway volume and resistances correlate better with PRO than conventional endpoints such as FEV1.