RT Journal Article SR Electronic T1 The relationship between pneumococcal antibody response patterns and asthma status JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA4056 DO 10.1183/13993003.congress-2015.PA4056 VO 46 IS suppl 59 A1 Rohit Divekar A1 Chung Il Wi A1 Miguel Park A1 Roshini Abraham A1 Young Juhn YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/PA4056.abstract AB Background: Asthma is known to be associated with invasive pneumococcal disease but little is known about relationship of 23-valent serotype-specific pneumococcal (PPV-23) antibody response and asthma status.Objectives: To identify patterns of PPV-23 response and relate to asthma status in adults.Methods: An exploratory prospective cohort study was conducted to measure 23 serotype-specific pneumococcal antibody titers (by ELISA) at baseline in otherwise healthy Olmsted County, MN residents. PPV-23 antibody titers were measured 4-6 weeks post-vaccination. Asthma status defined by predetermined criteria through medical record review. We performed graph analysis to model fold-change responses in individual patients across all serotypes. A bipartite graph (subjects and serotypes, as nodes) was generated & force directed/weighted degree centrality (WDC) algorithms applied to reveal inherent patterns in data.Results: 64 subjects were recruited [31 (48%) male, 58 (91%) white, mean age (±SD) 43.1 yrs (±13.8)], and history of asthma 18 (28%). Network revealed a core-periphery relationship of the subjects with the serotypes. Analysis revealed higher proportion of central nodes to be normal and asthmatics in periphery. The WDC of asthmatics was lower than those without (p=0.02). Lowest quartile WDC (poorest antibody responses) had a higher proportion of asthmatics (p=0.01) compared to those with greatest antibody response. The maximum fold change was for serotype 7F, followed by 4 and 6B.Conclusion: Simultaneous mapping of vaccine response reveals that subjects with poorer PPV-23 response (fold-change) were more likely to have asthma. We also observed serotype-specific differential antibody responses.