TY - JOUR T1 - Multi nuclear 3D multiple breath washout imaging with hyperpolarised <sup>3</sup>He and <sup>129</sup>Xe MRI JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA3752 VL - 46 IS - suppl 59 SP - PA3752 AU - Felix Horn AU - Madhwesha Rao AU - Neil Stewart AU - Helen Marshall AU - Juan Parra-Robles AU - Jim Wild Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA3752.abstract N2 - Introduction: Multiple breath washout (MBW) is a sensitive marker of early-stage lung disease. MBW imaging (MBWI) has recently been developed using hyperpolarised (HP) 3He MRI to regionally quantify ventilation heterogeneity (fractional ventilation) (Horn et al., J Appl Physiol,116(2):129-39,2014). 3He and 129Xe gases provide unique and complementary information about lung function due to their intrinsically different physicochemical properties (e.g. diffusion coefficient).Objective: To demonstrate MBWI with 129Xe and 3He using an optimised magnetic resonance imaging sequence and a novel dual-tuned radiofrequency coil.Methods: MBWI was performed on 5 healthy volunteers with an isotropic resolution of 1.2 cm3. Subjects remained stationary during the &lt;5 min gap between 3He and 129Xe scans so that data were coincident.Results: 3D MBWI using HP-129Xe has been shown for the first time. An example dataset of acquisitions from both tracer gases is shown in Fig.1A, highlighting the high signal-to-noise images. Fractional ventilation maps for all subjects exhibited similar features and ventilation heterogeneity for both HP-He and HP-Xe (Fig. 1B). Conclusion: The feasibility of MBWI with 3He and 129Xe has been demonstrated. In future work, it may be possible to identify differences in MBWI between these gases symptomatic of obstructive lung disease (e.g. position of the diffusion-convection front). ER -