TY - JOUR T1 - Comparison between anticholinergic and beta-2 agonist treatments by using pletismography and impulse oscillometry JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA3942 VL - 46 IS - suppl 59 SP - PA3942 AU - Francesco Bini AU - Giorgio De Bernardi AU - Noemi Grassi AU - Adriano Vaghi Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA3942.abstract N2 - COPD (chronic obstructive pulmonary disease) treatment includes both anticholinergic and beta-2 agonist inhaled bronchodilators which can relieve symptoms and reduce exacerbations. To evaluate the effect of bronchodilator drugs, FEV1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) are routinely measured, even if they don't often fully identify important mechanical modifications of the lung, e.g. hyperinflation. Body plethysmography and impulse oscillometry (IOS) can better evaluate lung function. We recruited 32 patients: 16 with COPD, 10 with ACOS (asthma COPD overlap syndrome) and 6 with bronchial asthma. Patients underwent spirometry, body pletismography and IOS on 1st day, then they received 100 µg dose of salmeterol on 2nd day and 322 µg dose of aclidinium bromide on 3rd day, repeating functional tests each day. All values bettered, reaching statistical significance, after both salmeterol and aclidinium treatment in bronchial asthma and in ACOS patients, while in COPD patients only sGaw, R5, R20 and AX reached statistical significance, even if all values improved. The percentage of improvement obtained with aclidinium was higher than that obtained with salmeterol in functional tests. Data correlation was then performed. High association was found between FEV1 and R5 and between R5, R20 and VR. Values of ACOS patients showed the strongest association. IOS can adequately measure lung resistance changes caused by inhaled bronchodilators, related to changes in lung volumes. Absolute values of bronchodilation and of reduction of both peripheral and central resistances obtained with aclidinium were greater than those got with salmeterol. ER -