RT Journal Article
SR Electronic
T1 Chronic effects of air pollution on lung function after lung transplant (SysCLAD)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3405
DO 10.1183/13993003.congress-2015.PA3405
VO 46
IS suppl 59
A1 Valérie Siroux
A1 Meriem Benmerad
A1 Rémy Slama
A1 Karine Botturi
A1 Johanna Claustre
A1 Antoine Roux
A1 Carine Gomez
A1 Romain Kessler
A1 Olivier Brugière
A1 Jean-François Mornex
A1 Sacha Mussot
A1 Marcel Dahan
A1 Véronique Boussaud
A1 Isabelle Danner-Boucher
A1 Claire Dromer
A1 Christiane Knoop
A1 Laure Malherbe
A1 Frederik Meleux
A1 Laurent Nicod
A1 Antoine Magnan
A1 Christophe Pison
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA3405.abstract
AB We studied the role of chronic exposure to ambiant air pollution on lung function level and evolution in lung transplant patients.The lung function of 525 lung transplant (LT) patients from the COLT cohort was followed-up. The 12-month average levels of air pollutants (Nitrogen dioxide (NO2), fine particulate matters (PM2.5, PM10) and ozone (O3)) were estimated at the home addresses of each patient. The effect of air pollutant exposure on FEV1 level and change in FEV1 both during the recovery and decline periodes were estimated using mixed linear regression models adjusted on recipient age, sex, smoking (donor and patient), body mass index, donor age, type of LT, underlying disease, sex and HLA mismatch, ischemia time, anti-HLA antibodies, Pseudomonas colonization, CMV infections, immunosuppression induction and acute rejection.The population included 54% of men and 81% of double LT (mean age 43yrs). The main underlying diseases were cystic fibrosis (40%), emphysema/COPD (34%) and pulmonary arterial hypertension (14%). Mean (sd) individual exposure levels were 15.2 (2.1), 22.1 (3.1), 18.1 (7.3) and 51.7 (8.2) µg/m3 for PM2.5, PM10, NO2 and O3, respectively. NO2 exposure was significantly associated with lower FEV1 levels measured during the recovery period and a non-significant trend was observed in the decline period (estimate (se) = -3.39(1.48) p=0.02 and -1.96(1.47) p=0.18). None of the air pollutants exposure was associated with change in FEV1.Our results suggest a potential deleterious effect of chronic exposure to NO2 on FEV1 level following LT and did not evidence an effect of air pollution on change in FEV1.Fundings: EU-FP7 SYSCLAD, Vaincre la Mucoviscidose, Association Gregory Lemarchal.