TY - JOUR T1 - Regional distribution of chest wall displacements in infants during high frequency oscillatory ventilation (HFOV) JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA1856 VL - 46 IS - suppl 59 SP - PA1856 AU - Martina Perego AU - Emanuela Zannin AU - Lara Marconi AU - Giulia Dognini AU - Maria Luisa Ventura AU - Tiziana Fedeli AU - Paolo Tagliabue AU - Raffaele Dellaca' Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA1856.abstract N2 - Background: Excised lungs expand asynchronously and nonuniformly during high frequency ventilation (Lehr 1985). Moreover, in healthy adults, pressure oscillations above 4 Hz applied at the mouth propagate inhomogeneously in the chest wall (Dellacà et al 2003).Objective: In newborn infants receiving HFOV, characterizing the regional heterogeneities of chest wall displacements at different oscillatory frequencies.Methods: We studied 14 newborns (gestational age=29±4 wks; postnatal age=7±8 days; body weight=1.2±0.7 Kg). The following frequencies were tested: 5, 8, 10, 12 and 15 Hz. For each frequency, the displacements of 24 passive markers placed on the infant's chest wall were measured by optoelectronic plethysmography. A subset of 6 points were used to evaluate chest wall movements in the cranio-caudal direction. For each marker we computed: the displacement normalized for the ventilation pressure amplitude, the phase shift vs. mrk 1.Results: Pressure oscillations propagation decreased with frequency and was higher in the abdominal than in the ribcage compartment (Figure 1 left). The asynchrony of displacements in the cranio-caudal direction increases with f (Figure 1 right). Conclusion: In infants receiving HFOV the chest wall oscillates asynchronously and non-uniformly. With increasing frequency the pressure oscillations propagation reduces with frequency, while asynchronies become more evident. ER -