RT Journal Article SR Electronic T1 EBUS in real life: Primary diagnosis and mediastinal staging JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA2988 DO 10.1183/13993003.congress-2015.PA2988 VO 46 IS suppl 59 A1 João Pedro Steinhauser Motta A1 Franz Stanzel A1 Axel Kempa A1 José Roberto Lapa e Silva YR 2015 UL http://erj.ersjournals.com/content/46/suppl_59/PA2988.abstract AB Since the first articles published for over 10 years, EBUS technique gained strong scientific background and became incorporated into routine practice of pulmonology and thoracic surgery centers. How is EBUS performing in real life outside the scientific environment is an interesting question.We present a single-center retrospective study of 439 consecutive cases of patients who, during the period from January 2010 to August 2012, were submitted to EBUS and thoracic surgery. Procedures were performed in the Lungenklinik Hemer. Biopsies obtained by EBUS-TBNA were compared with those provided during surgical exploration. Primary outcome was accuracy of EBUS for diagnosis of lung cancer. Secondary endpoint was comparison of EBUS performance with PET-CT and mediastinoscopy for mediastinal staging. Results: 152 cases were excluded for not having lymph node sampling by both EBUS and surgery. 287 patients underwent EBUS and surgery, 124 PET-CT and 20 mediastinoscopy. Accuracy of EBUS for lung cancer diagnosis was 97%. Accuracy of EBUS, PET-CT and mediastinoscopy for mediastinal staging was 89,5%, 77,2% and 80% respectively. 27 patients with negative mediastinal staging by EBUS were positive after surgery. 21 of these patients did not undergo PET-CT before EBUS.13 of these patients had only lymph nodes metastases not accessible by EBUS.Applied in routine practice EBUS is an excellent tool for the diagnosis of lung cancer and superior to PET-CT and mediastinoscopy for mediastinal staging. The information obtained by PET-CT should not be underestimated in contributing to EBUS performance. We need to be aware of the limitation of EBUS for some lymph node regions before the decision by surgery.