RT Journal Article
SR Electronic
T1 Influence of the association of smoking, COPD and rpulmonary tuberculosis on diffusion lung capacity
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4534
DO 10.1183/13993003.congress-2015.PA4534
VO 46
IS suppl 59
A1 Kiryukhina, Larisa
A1 Volodich, Olga
A1 Gavrilov, Pavel
A1 Pavlova, Maria
A1 Archakova, Liudmila
A1 Nefedova, Natalia
A1 Aganezova, Elena
A1 Zilber, Elmira
A1 Yablonskiy, Piotr
YR 2015
UL https://publications.ersnet.org//content/46/suppl_59/PA4534.abstract
AB Association between smoking, COPD and Pulmonary tuberculosis (PT) is often under estimated. Most of patients with PT are smokers and may often have co-morbidity as COPD.Aims: to evaluate the effect of smoking and COPD on outcomes of diffusion lung capacity in patients with PTMethods: 82 patients with PT with infiltrates in 1-3 segments and disease duratuion till 1 year are examined. 1 group - 35 non-smokers, 2 - 29 smokers without signs of COPD (9,0 pack-years of smoking, 95% CI 3,7-14,3), 3 - 18 patients with COPD (37,8 pack-years, 95% CI 19,3-56,2). We used spirometry, bodyplethysmography, measurement of diffusion capacity for carbon monoxide by single breath method (DLCO) on MasterScreen Body Diffusion (VIASYS healthcare), Computed tomography on TOSHIBA AQUILION 32. We used descriptive statistics and Spearman correlation analysis (Statistica, statSoft Inc., USA).Results: There were not significant ventilation disorders in groups 1 and 2. DLCO was moderately decreased in both groups. But only non-smokers had significantly more DLCO vs patients with COPD (78,7±11,2 vs 66,7±11,3, p<0,05). DLCO in smokers and COPD patients was not significantly different (74,4±11,7 vs 66,7±11,3, p>0,05). There was an increase in hemoglobin from group 1 to 3 (12,8; 14,2; 15,2; p<0,01 gr. 1 and 2, gr. 1 and 3). The correlation analysis revealed an association between DLCO, air trapping volume, Hb and the pack-years of smoking (-0,41; 0,37; 0,45; p<0,05).Conclusions: The patients who had the association COPD and PT had most significant decrease of DLCO, but mean value of DLCO in smokers and COPD patients was not significantly different. DLCO decreasing was associated with the pack-years of smoking.