RT Journal Article
SR Electronic
T1 The prognostic impact of PD1 and PDL1 expression in non-small cell lung cancer
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4244
DO 10.1183/13993003.congress-2015.PA4244
VO 46
IS suppl 59
A1 Lars Henning Schmidt
A1 Andreas Kümmel
A1 Dennis Görlich
A1 Michael Mohr
A1 Sebastian Bröckling
A1 Inga Grünewald
A1 Eva Wardelmann
A1 Anne Schultheis
A1 Jan-Henrik Mikesch
A1 Benedikt Vietmeier
A1 Carsten Müller-Tidow
A1 Alessandro Marra
A1 Christoph Schliemann
A1 Wofgang E. Berdel
A1 Wolfgang Hartmann
A1 Wiewrodt Rainer
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA4244.abstract
AB Introduction: To improve the prognosis of lung cancer patients, immunotherapy is expected to become a powerful therapeutic option. Several clinical studies demonstrate a positive prognostic effect of a targeted therapy against the programmed cell death receptor PD1 and its ligand PDL1 in solid tumors. For non-small lung cancer (NSCLC) however, the diagnostic, prognostic and predictive impact of these factors needs to be clarified.Materials and Methods: Immunohistochemistry was performed to evaluate the expression profile of PD1 and PDL1 in 398 NSCLC patients (median age: 66 years, 78% male sex, 45% squamous cell carcinoma (SCC) histology). Statistical analysis included Fisher's Exact test, univariate and multivariate models.Results: 23% of the NSCLC samples expressed PDL1 and 11% of the investigated tumors displayed PD1 in tumor infiltrating lymphocytes (TILs). A positive correlation with PD1-positive lymphocytes was found for male sex (p=0.022), age below 70 years (p=0.039), adjuvant therapy (p=0.018) and Bcl-2 protein expression (p=0.012). PDL1 was associated with increased overall survival in SCC (p=0.031, log rank test; p=0.007, multivariate cox regression model: HR(95%CI)= 0.494(0.296-0.825)).Conclusion: In the context of immunotherapeutic approaches we present a histology-depending prognostic effect of PDL1 for NSCLC patients with SCC. With regard to the observed effect, further studies are required to evaluate the prospective impact of PD1 and PDL1 in NSCLC.