RT Journal Article
SR Electronic
T1 Metapneumovirus infection vs. metapneumovirus and RSV coinfection. Is there a difference?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3622
DO 10.1183/13993003.congress-2015.PA3622
VO 46
IS suppl 59
A1 Kenneth Escobar
A1 Astrid Godinez
A1 Estuardo Funes Merida
A1 Fabiola Moscoso
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA3622.abstract
AB Introduction: A rationale of a child with bronchiolitis coninfected with human Metpaneumovirus (hMPV) and Respiratory Syncytial Virus (RSV) would produce a worse clinical scenario than those only infected with hMPV.Aim: To compare clinical, basic laboratory and X ray data in a group of children infected with hMPV vs. a group of children coinfected with hMPV+RSV.Methods: A clinical case series study that included all patients that were admitted to our pediatrics ward with diagnosis of bronchiolitis due to hMPV or hMPV+RSV infection detected by a polymerase chain reaction test in a nasopharyngeal aspirate from 2009 to 2012.Results: 152 clinical files, 136 from hMPV group and 16 from hMPV+RSV group. Females were the most affected in both groups, ages in the hMPV group were 20±24 months and in the hMPV+RSV group were 16±27 months. Hospital stay was the same for both groups 7±5 days. One patient required mechanical ventilation in hMPV+RSV group and 7 patients required it in the hMPV group. One death was reported in the hMPV group. Laboratory data included an hemogram that in most cases a discrete leukocytosis was seen with no remarkable changes in the distribution of white blood cells; C reactive protein levels of 50±65 mg.dl-1 in hMPV group and 61±75 mg.dl-1 in hMPV+RSV group. On chest X ray the alveolar radiological pattern dominated on both groups. Cough, fever and tachypnea were, among others, the more prevalent clinical signs and symptoms in both groups. No statistically significant differences were found in all the variables studied.Conclusions: Being coinfected with hMPV+RSV does not increase the risk of having worse clinical manifestations nor death rate that being infected with hMPV only.