TY - JOUR T1 - Age-specific mortality among tuberculosis-patients in Denmark 1998-2010 JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA2712 VL - 46 IS - suppl 59 SP - PA2712 AU - Andreas Fløe AU - Ole Hilberg AU - Christian Wejse AU - Anders Løkke AU - Jakob Kjellberg AU - Rikke Ibsen AU - Poul Jennum Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA2712.abstract N2 - Objective: To evaluate the age-specific mortality in a national TB cohort, and to estimate relative age-specific mortality compared with matched controls, in a retrospective case-control study.Methods: Using Danish National Patient Registry, we retrospectively identified TB-patients between 1998-2010. They were matched to controls by age, gender, civil status and geography. Mortality data were obtained from Danish Civil Registration System. We calculated age-specific hazard ratio and cumulative survival function, adjusting for varying follow-up, distributing.Results: 6713 cases and 28217 controls were followed for max. 12 (span: 0-12) years. Mortality was higher for cases than controls in all age groups, and significantly so for age groups above 20 years, peaking at a Hazard Ratio of 8.7 (95% CI: 5.53;16.69) in the 30-39 years age. Absolute difference in mortality increased with older age. Age groupCases, NMortality share, CasesControls, NMortality share, ControlsHazard ratioP-value0-9 years3740.5 %16090.2 %2.840,254310-19 years4590.7 %21160.2 %4.090.084420-29 years7861.7 %34740.3 %7.510.000030-39 years11375.1 %48830.6 %8.700.000040-49 years113914.0 %47472.8 %5.850.000050-59 years94427.6 %38136.1 %5.680.000060-69 years73740.8 %301012.5 %4.340.000070-79 years72356.0 %291130.0 %2.610.000080+ years41474.6 %165455.6 %2.000.0000Absolute mortality for cases and controls, and hazard ratio of mortality, adjusted for varying follow-up.Conclusion: Cumulative mortality of TB-patients is significantly inferior to matched controls. While the difference in survival is substantial among elderly patients, a high relative risk of dying is particularly of concern among young and middle-aged adult TB patients. ER -