TY - JOUR T1 - Hemodynamic consequences of NIV during acute respiratory failure. A prospective echocardiographic study JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.OA500 VL - 46 IS - suppl 59 SP - OA500 AU - Bouchra Lamia AU - Stephanie Van Mossevelde AU - Luis-Carlos Molano AU - Antoine Cuvelier AU - Jean-Francois Muir Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/OA500.abstract N2 - Introduction: In acute respiratory failure patients, the increased negativity of intrathoracic pressure (ITP) during inspiration induces an increase of venous return pressure gradient, right ventricular (RV) afterload and left ventricular ejection pressure gradient. Few studies have non invasively reported hemodynamic effetcs of NIV in acute respiratory faiure pateints. We aimed to analyse with echocardiography such hemodynamic consequences.Méthodes: Prospective study. Transthorcaic echocardiography (TTE) images were recorded during spontaneous breathing activity and during NIV. Parameters of preload, afterload, diastolic function and contractlity were measured. Speckle tracking technic analysis was applied to 2D echo images.Résultats: Thirteen patients were included (69(11) y; 9 CHD and 11 CRD. NIV (ST mode, PS=14(2) cm2 , O2 = 7 (6) L/min.) significantly improved LV systolic function: LVEF: 59(6) vs 66 (6)%, p=0.01 ; SV: 61 (9) vs 65 (12) ml, p = 0.05, LV diastolic function : Ea wave 11(2) vs 9(2), p=0.01, RV afterload : decreased of TR velocity from 3,42 (0,44) to 3,02 (0,57) m/sec, p = 0.01. RV synchrony measured by seckle tracking strain was also improved: 235 (140) vs 182 (149) msec, p =0.04.Conclusion: During acute respiratory failure preload, afterload and contractility are affected. In our study TTE analysis showed marked improvement in LV and RV function and better understanding of NIV induced heart lung interactions for a best treatment adjustment. ER -