RT Journal Article
SR Electronic
T1 Clinical significance of transcutaneous PCO2 in patients with obstructive sleep apnea syndrome
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA2348
DO 10.1183/13993003.congress-2015.PA2348
VO 46
IS suppl 59
A1 Tadashi Sakaguchi
A1 Osamu Hataji
A1 Haruko Saiki
A1 Esteban C. Gabazza
A1 Corina D'Alessandro-Gabazz
A1 Yoichi Nishii
A1 Tetsu Kobayashi
A1 Osamu Taguchi
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA2348.abstract
AB Background: The severity of obstructive sleep apnea syndrome (OSAS) has been defined by the frequency of apnea hypopnea index (AHI) and by the daytime of sleepiness. The role of hypercapnia as a contributing factor in the severity of the disease in patients with obstructive sleep apnea syndrome (OSAS) has not been so far assessed. Objective: In the present study, we measured transcutaneous PCO2 (tc-PCO2) and evaluated whether it correlates with markers of disease severity in OSAS patients. Subjects and Methods: There were 102 patients with OSAS (male, 81; female, 21; mean age, 58.2 ± 14.4 years old). Overnight polysomnography (PSG-TOSCA500, Japan) with non-invasive tc-PCO2 were performed in patients from January 2014 through June 2014. Results: The mean body mass index was 25.8 ± 4.4 kg/m2 and the mean body weight 71.1 ± 15.6 kg. The mean AHI was 26.9 ± 20.5 (times/hour). The tc-PCO2 and AHI were not significantly correlated during the total sleep time. However, the tc-PCO2 was significantly elevated during REM sleep compared to that during non-REM sleep (51.1 ± 5.5 vs 49.6 ± 4.9; p<0.001); this difference in tc-PCO2 tended to be higher in subjects with high AHI.Conclusion: This study showed that the obstructive condition worsens during REM sleep and that it is associated with increased tc-PCO2, suggesting the clinical significance of tc-PCO2 in patients with OSAS.