TY - JOUR T1 - Phenotypical heterogeneity of severe COPD subjects: Baseline results from the Czech multicentre research database of COPD JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.OA2925 VL - 46 IS - suppl 59 SP - OA2925 AU - Vladimir Koblizek AU - Marek Plutinsky AU - Jaromir Zatloukal AU - Patrice Popelkova AU - Tomas Dvorak AU - Petr Safranek AU - Ondrej Sobotik AU - Alena Vlachova AU - Petr Vanik AU - Zuzana Liptakova AU - Lucie Heribanova AU - Blanka Snelerova AU - Pavlina Musilova AU - Maria Majerciakova AU - Tomas Vencalek AU - Eva Kocova AU - Barbora Novotna AU - Michal Kopecky AU - Ondrej Kudela AU - Katerina Neumannova AU - Kristian Brat AU - Eva Volakova AU - Karel Hejduk AU - Jan Svancara AU - Jiri Jarkovsky AU - Michal Svoboda AU - Zuzana Zbozinkova Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/OA2925.abstract N2 - Background: The COPD has been recognized as a multiple-faced syndrome. Heterogeneity features of severe COPD patients still remains unknown.Aim: Systematic observation of the variety of symptoms and other clinical characteristics of severe airflow limitation subjects.Methods: The Czech Multicentre Research Database of COPD (Database) is a multicenter, observational, and prospective study of patients with post bronchodilator FEV1≤60%(NCT01923051). Every consecutive patient, who fulfils the inclusion criteria, is asked to participate in the study. Baseline data includes parameters used for identification of clinical phenotypes.Results: We have enrolled 488 patients from Aug13 to Dec14, 343 of them with complete set of parameters for phenotype assessment (250males,67.0 years,FEV143.0%,6.7% non-smokers). We found all GOLD categories (A 4.4%,B 14.9%,C 3.8%,D 73.8%) and six COPD phenotypes (bronchitic-b 75.5%,emphysematous-e 77.4%,exacerbators-ex 34.7%,bronchiectatic-be 28.4%,cachectic-ca 16.3%,ACOS-ac 4.2%) in our severe COPD cohort. Clinical assessment of phenotypes (without computer tomography) have high sensitivity (0.69-0.74) in majority of them (except be) and excellent specificity in all (0.71-0.99). Some phenotypes are significantly associated with more symptoms (fatigue in b,ex and dyspnea in ex,ca) greater value of BODE index (e,ex,ca), higher values of specific CAT items (b,ca,ex). Contrary e,ac,be COPD have not any CAT items predominance.Conclusion: 1st analysis of baseline data of the Database has confirmed the wide clinical distribution of COPD syndrome. Subjective evaluation by physicians achieves satisfactory sensitivity and specificity. ER -