RT Journal Article
SR Electronic
T1 MIG and IP-10 levels in induced sputum of stable and exacerbated COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3885
DO 10.1183/13993003.congress-2015.PA3885
VO 46
IS suppl 59
A1 Solveig Tangedal
A1 Marianne Aanerud
A1 Louise J.P. Persson
A1 Per S. Bakke
A1 Tomas M.L. Eagan
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA3885.abstract
AB Background: The CXCR3 ligands CXCL9 (MIG) and CXCL10 (IP-10) are found elevated in sputum and blood of COPD patients. CXCR3-ligand interaction attracts Th1 cells and may be implicated in COPD pathogenesis.Aims: To explore levels of MIG and IP-10 in induced sputum from healthy controls and COPD patients both in stable state and at exacerbations.Methods: 43 controls and 253 patients from the Bergen COPD Cohort study, and 56 patients from the Bergen COPD Exacerbation Study were included. Inflammatory markers were measured by a bead-based immunoassay.Non-parametric tests were used for bivariate comparisons, and outcome variables were logtransformed in regression analyses.Results: In stable COPD compared to healthy controls, sputum MIG levels were significantly higher (median 208 versus 80 pg/ml, p<0.01), whereas exacerbation levels were not different to stable COPD levels. In contrary, sputum IP-10 levels were not different in stable COPD to controls, but significantly higher during exacerbation in COPD (median 484 vs 236 pg/ml, p<0.01)In bivariate analyses, male sex, higher age, ex-smoking, COPD stage and exacerbation frequency were associated with significantly higher levels of MIG in stable COPD compared with controls. Correspondingly, male sex, higher age and ex-smoking were predictive of higher IP-10 in stable COPD. In adjusted regression models, male sex, ex-smoking and exacerbation frequency was significantly associated with both higher MIG and IP-10.Conclusions: Both MIG and IP-10 may serve as markers for a higher airway inflammatory state, IP-10 possibly more specifically in inflammation caused by microbial stimuli. Interestingly, smoking appeared to suppress the response of both ligands.