RT Journal Article
SR Electronic
T1 LATE-BREAKING ABSTRACT: Early following up of gas trapping with computed tomography during normal breathing in infant with Cystic Fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA1294
DO 10.1183/13993003.congress-2015.PA1294
VO 46
IS suppl 59
A1 Saguitaah, magalie
A1 Rémi, Gauthier
A1 Duboibaudry, Cécile
A1 Couder, Laure
A1 Metges, Marie Agnes
A1 Lebourgeois, Muriel
A1 Reix, Phillipe
A1 Amsallem, Francis
A1 Molinari, Nicolas
A1 Matecki, Stefan
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA1294.abstract
AB Aim: To determine the repeatability and the discriminate validity of gas trapping score in infants with cystic fibrosis (CF) using thoracic computed tomography imaging during normal breathing (CT-b).Method: 41 CF infants were included with 2 CT-b respectively at 10.5 ± 1.7 and 57.5 ± 6.0 weeks old. Imagings were compared to healthy infants groups of similar age. At end expiratory level, image was acquired with 0.4 s of exposition time. Images was acquired 1 cm below the interclavicular notch, and interval between images was 5 mm for the first and 8 mm for the second CT-b. The extent of gas trapping for each of the 6 Zones (upper, mid, and lower; right and left) was graded as: absent = 0, <50% = 1; >50% = 2. Images were read in random order, on a soft copy reporting station and were analyzed twice in blind test at 6 month interval by the same pediatric thoracic radiologist. Results are express as Z-score created from our healthy control.Results: All CT-b scan showed a good concordance between the 2 scores: ICC = 0.98 [ 0.97 , 0.99 ]. In our CF compare to healthy infants, we observed a significant increase of air trapping score expressed in Z-score, at 10 weeks (4.4 ± 5.1 vs 0.64 ± 1.0) and 13 month old (7.52 ± 9.7 vs 0.56 ± 0.7). At 10 weeks old 50 % of our CF infants and 70 % at 13 month present a Z score for air trapping higher then 1.64.Conclusion: In a ethical context which will progressively reduces the possibility to sedate infants for lung exploration, with the constant decrease of exposition time due to technical progress, CT-b could be an alternative method without anesthesia, to evaluate presence of gas trapping in young CF infant.