PT  - JOURNAL ARTICLE
AU  - magalie Saguitaah
AU  - Gauthier Rémi
AU  - Cécile Duboibaudry
AU  - Laure Couder
AU  - Marie Agnes Metges
AU  - Muriel Lebourgeois
AU  - Phillipe Reix
AU  - Francis Amsallem
AU  - Nicolas Molinari
AU  - Stefan Matecki
TI  - LATE-BREAKING ABSTRACT: Early following up of gas trapping with computed tomography during normal breathing in infant with Cystic Fibrosis
AID  - 10.1183/13993003.congress-2015.PA1294
DP  - 2015 Sep 01
TA  - European Respiratory Journal
PG  - PA1294
VI  - 46
IP  - suppl 59
4099  - http://erj.ersjournals.com/content/46/suppl_59/PA1294.short
4100  - http://erj.ersjournals.com/content/46/suppl_59/PA1294.full
SO  - Eur Respir J2015 Sep 01; 46
AB  - Aim: To determine the repeatability and the discriminate validity of gas trapping score in infants with cystic fibrosis (CF) using thoracic computed tomography imaging during normal breathing (CT-b).Method: 41 CF infants were included with 2 CT-b respectively at 10.5 ± 1.7 and 57.5 ± 6.0 weeks old. Imagings were compared to healthy infants groups of similar age. At end expiratory level, image was acquired with 0.4 s of exposition time. Images was acquired 1 cm below the interclavicular notch, and interval between images was 5 mm for the first and 8 mm for the second CT-b. The extent of gas trapping for each of the 6 Zones (upper, mid, and lower; right and left) was graded as: absent = 0, <50% = 1; >50% = 2. Images were read in random order, on a soft copy reporting station and were analyzed twice in blind test at 6 month interval by the same pediatric thoracic radiologist. Results are express as Z-score created from our healthy control.Results: All CT-b scan showed a good concordance between the 2 scores: ICC = 0.98 [ 0.97 , 0.99 ]. In our CF compare to healthy infants, we observed a significant increase of air trapping score expressed in Z-score, at 10 weeks (4.4 ± 5.1 vs 0.64 ± 1.0) and 13 month old (7.52 ± 9.7 vs 0.56 ± 0.7). At 10 weeks old 50 % of our CF infants and 70 % at 13 month present a Z score for air trapping higher then 1.64.Conclusion: In a ethical context which will progressively reduces the possibility to sedate infants for lung exploration, with the constant decrease of exposition time due to technical progress, CT-b could be an alternative method without anesthesia, to evaluate presence of gas trapping in young CF infant.