RT Journal Article
SR Electronic
T1 Oxidative stress is associated with muscle wasting after aortic surgery
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA2149
DO 10.1183/13993003.congress-2015.PA2149
VO 46
IS suppl 59
A1 Richard Paul
A1 Mattia Gomarasca
A1 Eleonora D'Angelo
A1 Lisa Barbaro
A1 Gregory Quinlan
A1 Mark Griffiths
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA2149.abstract
AB ICU Acquired Paresis (ICUAP) leads to prolonged recovery and reduced quality of life in survivors of ICU. Patients undergoing aortic surgery experience an ischaemia-reperfusion (IR) injury mimicking the SIRS/sepsis response. 50% of patients demonstrate muscle loss post-operatively, representing a homogenous cohort to study the pathogenesis of ICUAP.Objectives: To investigate if oxidative stress in these patients correlated with loss of muscle bulk in the post-operative periodTo assess a new system for measuring oxidative stress (RedoxSysTM) that measures static (sORP) and capacity (cORP) oxidation-reduction potential and compare it to conventional markersMethods: 11 Patients undergoing major aortic surgery were grouped post-hoc into either wasters (n=6) or non-wasters (n=5) based on serial rectus femoris ultrasound measurements (≤ or ≥ 10% muscle bulk loss). Serum samples (day 0,1,3 & 7) post-operatively were tested for sORP, cORP and a marker of ischaemia (xanthine) by HPLC.Results: 24-hours following surgery, sORP increased (17.2% vs 4.3%, p =0.03) and cORP decreased (46.7% vs 29.6%, p = 0.004) significantly more in wasters compared to non-wasters. Both returned to baseline by the 7th post-operative day in non-wasters but cORP remained persistently reduced in wasters (32.9% vs 12.0%, p=0.04). Serum xanthine was persistently raised in wasters compared to non-wasters across all time points.Conclusion: Oxidative stress following aortic surgery was persistently raised in patients with muscle wasting compared to those without. The RedoxSYS system agreed with another surrogate of oxidative stress. Further investigation of its utility in monitoring the degree of oxidative stress is warranted.