TY - JOUR T1 - Complications and mortality of tranbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA2031 VL - 46 IS - suppl 59 SP - PA2031 AU - Claudia Ravaglia AU - Sara Tomassetti AU - GianLuca Casoni AU - Carlo Gurioli AU - Sara Piciucchi AU - Christian Gurioli AU - Stefano Sanna AU - Dubini Alessandra AU - Poletti Venerino Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA2031.abstract N2 - Background: diagnosis of interstitial lung disease (ILD) includes surgical lung biopsy (SLB) when clinical and radiological data are inconclusive, but transbronchial cryobiopsy (TBCB) is acquiring an important role. The main purpose of this study retrospective observational was to investigate the differences in mortality and complications between TBCB and SLB performed with VATS.Methods: we evaluated all patients with ILD from January 2004 to August 2014 at our Institution; 155 patients underwent SLB and 241 TBCB. All values were described as mean ±standard deviation; a chi-square statistics test was used for categorical data and an unpaired Student's t test for continuous data.Results: The mean age of the patients was similar in the two groups (57,74 ± 11,29 in SLB group vs 56,70 ± 11,29 years in TBCB group). Mortality and complications were evaluated at 30 and 90 days. In the SLB group mortality was observed in 3,9 % of patients and minor complications were experienced in 10,6 % of patients. In the TBCB group the most frequent complication was pneumothorax (19,9%) but only 20% required drainage; we observed prolonged bleeding only in one case and only one patient died (0,41%), who was HIV-positive and died of acute exacerbation of IPF. Chest tube drainages after VATS were maintained for 3,6 days (2-9 days) and duration of hospitalization was 5,2 days; in case of iatrogenic pneumothorax in the TBCB, drainage was maintained for 4,1 days and mean hospitalization after bronchoscopy was 2,9 days.Conclusion: TBCB has advantages of decreased mortality and complication and can be safer than SLB in the diagnosis of ILDs, with also a shorter mean hospitalization. ER -