RT Journal Article
SR Electronic
T1 The role of sustained physical inactivity in the progression of exercise intolerance and muscle depletion in COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3550
DO 10.1183/13993003.congress-2015.PA3550
VO 46
IS suppl 59
A1 Benjamin Waschki
A1 Anne Kirsten
A1 Olaf Holz
A1 Kai-Christian Müller
A1 Miriam Schaper
A1 Anna-Lena Sack
A1 Thorsten Meyer
A1 Klaus Rabe
A1 Helgo Magnussen
A1 Henrik Watz
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA3550.abstract
AB Background: COPD is characterized by exercise intolerance, muscle depletion, and physical inactivity. The aim of this study was to analyze the role of sustained physical inactivity for changes in exercise capacity and skeletal muscle mass in the course of COPD.Methods: In this cohort study, we measured physical activity level (PAL; total daily energy expenditure / resting metabolic rate) via multisensory armband, FEV1, 6-minute walk distance (6MWD), and fat-free mass (FFM; bioelectrical impedance) at baseline and after 3 years in 170 patients with COPD (GOLD stage I–IV) and 30 with chronic bronchitis. Patients were longitudinally classified into ”sustained physical inactivity” (i.e. PALT0+T1 <1.40) or ”some level of activity” (i.e. PALT0orT1 >1.40).Results: During follow-up, we found a significant decrease in PAL, FEV1, 6MWD, and FFM (p <0.001, respectively). Independent of FEV1, sustained physical inactivity was related to a greater decline in 6MWD and FFM compared to that in patients with some level of activity (difference, 21 m/yr and 0.81 kg/yr). Sustained physical inactivity was not related to an accelerated decline in FEV1. View this table:Table 1. Annual decline in FEV1, 6MWD, and FFM according to longitudinal PAL groupsConclusions: Sustained physical inactivity over time promotes a progression of exercise intolerance and muscle depletion in patients with COPD.