PT - JOURNAL ARTICLE AU - Merete S. Engeseth AU - Hege Clemm AU - Ola Røksund AU - Knut Øymar AU - Trond Markestad AU - Thomas Halvorsen AU - Maria Vollsæter TI - Better respiratory outcomes for extremely preterm born children AID - 10.1183/13993003.congress-2015.OA4763 DP - 2015 Sep 01 TA - European Respiratory Journal PG - OA4763 VI - 46 IP - suppl 59 4099 - http://erj.ersjournals.com/content/46/suppl_59/OA4763.short 4100 - http://erj.ersjournals.com/content/46/suppl_59/OA4763.full SO - Eur Respir J2015 Sep 01; 46 AB - Introduction: Impaired pulmonary function (PF) is reported after extremely preterm (EP) birth. Better perinatal management facilitates survival of more immature infants, potentially influencing outcomes.Aim: Compare PF in two cohorts of EP-born.Methods: Two population-based cohorts of EP and term-born subjects born in Western Norway in 1991-92 (35 EP-born, 35 term-born) and 1999-2000 (57 EP-born, 54 term-born) were compared. Inclusion criteria were BW<1000 g vs. <1001 g and gestational age (GA)<28 weeks vs. <29 weeks in 1999-2000 and 1991-92, respectively. EP-born were split by bronchopulmonary dysplasia (BPD), defined as oxygen supplementation at GA 36 weeks. PF were examined at age 10-11 years.Results: Mean survival after admittance to neonatal intensive care was 81% in 1999-2000 vs. 76% in 1991-92 (p=0.57). Mean PF-difference between term and EP-born with BPD was lower in 1999-2000 vs. 1991-92, z-FEV1 (0.43 vs. 1.46;p=0.02), z-FVC (0.01 vs. 0.51;p<0.001), z-FEV1/FVC (0.62 vs. 1.51;p=0.03), z-FEF25-75% (0.72 vs. 1.72;p=0.04), z-RV (0.31 vs. -0.79;p=0.02) and RV/TLC (1.0 vs. -5.8;p=0.03). The z-FEV1- difference disappeared with adjustment for antenatal steroids and surfactant administration, both administered more frequently in 1999-2000. In 1999-2000, z-BW was the only predictor of z-FEV1 (B=0.24;p=0.04;R2=0.10), in 1991-92 z-BW (B=0.35;p=0.02) predicted z-FEV1 also with days of oxygen (B=-0.011;p<0.001) and antenatal corticosteroids (B=0.59;p=0.03) (R2=0.48).Conclusion: PF was better for EP-born in 1999-2000 compared to 1991-92, particularly in those with BPD. The findings suggest better neonatal care leads to better pulmonary outcomes, despite increased survival of immature infants.