PT - JOURNAL ARTICLE AU - David Ruttens AU - Stijn Verleden AU - Esmee Bijnens AU - Ellen Winckelmans AU - Jens Gottlieb AU - Gregor Warnecke AU - Federica Meloni AU - Monica Morosini AU - Davide Piloni AU - Wim Van der Bij AU - Erik Verschuuren AU - Gerhard Weinreich AU - Markus Kamler AU - Urte Sommerwerck AU - Antonio Roman AU - Susana Gomez-Olles AU - Cristina Berastegui AU - Christian Benden AU - Are Holm AU - Martin Iversen AU - Hans-Henrik Schultz AU - Bart Luijk AU - Erik-Jan Oudijk AU - Diane Van Kessel AU - Johanna Kwakkel-van-Erp AU - Peter Jaksch AU - Walter Klepetko AU - Nikolaus Kneidinger AU - Claus Neurohr AU - Paul Corris AU - Andy Fisher AU - Gerard Meachery AU - Jim Lordan AU - Elly Vandermeulen AU - Hannelore Bellon AU - Barbara Hoffmann AU - Kees De Hoogh AU - Danielle Vienneau AU - Gerard Hoek AU - Benoit Nemery AU - Geert Verleden AU - Robin Vos AU - Tim Nawrot AU - Bart Vanaudenaerde TI - The impact of long-term air pollution and traffic on outcome after lung transplantation in Europe AID - 10.1183/13993003.congress-2015.OA3270 DP - 2015 Sep 01 TA - European Respiratory Journal PG - OA3270 VI - 46 IP - suppl 59 4099 - http://erj.ersjournals.com/content/46/suppl_59/OA3270.short 4100 - http://erj.ersjournals.com/content/46/suppl_59/OA3270.full SO - Eur Respir J2015 Sep 01; 46 AB - It has been suggested that air pollution influences survival after lung transplantation (LTx).We investigated the association of long-term exposure to fine particles and traffic with mortality and chronic lung allograft dysfunction (CLAD).In 13 European LTx centers, patient characteristics were retrospectively collected. Patients transplanted <1990, early death (<90 days) and living>700 km from LTx center were excluded, resulting in 5,707 LTx patients. We estimated long-term particulate matter (PM10) exposure at home addresses with temporally adjusted land-use regression models and total road length within buffers zones around the home and using Cox regression. We associated this with incidence of CLAD and mortality, separately for patients taking macrolides or not. During follow-up (median 4.2 y), 2,767 patients developed CLAD and 2,718 died. In patients not taking AZI (n=3,551) air-pollution was associated with mortality and CLAD independent of covariates.The risk for dying increased by 22.0% for patients living in an area above the WHO air pollution standards (20 µg/m³) compared with residence <20 µg/m³. The density of roads within a 50-to-500m buffer zone around the home address was also associated with mortality and CLAD. No associations were observed in the macrolide-group (n=2,156).Air pollution is associated with worse prognosis after LTx and macrolides may prevent air pollution induced mortality.