TY - JOUR T1 - Prospective study of menopause and adult-onset asthma: The E3N French cohort JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.OA2940 VL - 46 IS - suppl 59 SP - OA2940 AU - Bobette Matulonga AU - Dominique Courbon AU - Agnès Forrnier AU - Annabelle Bédard AU - Sylvie Mesrine AU - Margaux Sanchez AU - Gabriel Thabut AU - Françoise Clavel AU - Raphaëlle Varraso AU - Bénédicte Leynaert Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/OA2940.abstract N2 - While it is acknowledged that asthma incidence increases after puberty in women, it is unknown whether asthma incidence may change after menopauseAim: To investigate the relationships between menopause and asthma incidenceMethods: We studied asthma-onset in 68,575 women free of asthma at baseline (mean age 51.2 yrs) and followed-up for 10.4 yrs as part of E3N. Proportional hazard models with menopausal status included as a time-dependent variable were used. Analysis was stratified by use of menopause hormone therapy (MHT) reported at the end of follow-upResults: Asthma-onset was positively associated with younger age, smoking, obesity, increase in BMI over the follow-up and use of MHT. Crude asthma incidence rates are provided in Table. The incidence of asthma was higher after natural menopause as compared to before menopause in MHT ever users (aHR=1.26 95%CI 1.01-1.56), but not in MHT non-users (adjusted HR=1.00 95%CI 0.72-1.40). Women with surgical menopause had a higher risk of asthma onset as compared to women with natural menopause in both MHT never-users (aHR=1.35 95% CI 0.95-1.93; p=0.09) and MHT-users (aHR=1.41 95%CI 1.11-1.79).Conclusion: Menopause transition is not associated with changes in asthma incidence in women with natural menopause not using hormonal treatment. A surgical menopause could increase the risk of asthma onset. MHT never usersMHT ever usersEventPYIncidence (95% CI)EventPYIncidence (95% CI)before menopause118826771.43 (1.17-1.69)1311022461.28 (1.06-1.50)after natural menopause1691326441.27 (1.08-1.46)4733230351.46 (1.33-1.59)after surgical menopause42238591.76 (1.23-2.29)82385852.13 (1.67-2.59)Crude incidence rates of asthma according to menopause ER -