PT - JOURNAL ARTICLE AU - Carissa Yap AU - Paul Hakendorf AU - Richard Woodman AU - David Lance AU - John Leung AU - Jeffrey Bowden AU - Anand Rose TI - Outcomes of radical treatment of early stage non-small cell lung cancer AID - 10.1183/13993003.congress-2015.PA4830 DP - 2015 Sep 01 TA - European Respiratory Journal PG - PA4830 VI - 46 IP - suppl 59 4099 - http://erj.ersjournals.com/content/46/suppl_59/PA4830.short 4100 - http://erj.ersjournals.com/content/46/suppl_59/PA4830.full SO - Eur Respir J2015 Sep 01; 46 AB - Background: Surgery and radiotherapy with radical intent are accepted modalities of treatment of early stage non-small cell lung cancer (NSCLC) (Stage 1A to 2B). The outcomes (mortality and recurrence) and the impact of comorbidities on outcomes in the clinical practice setting are not known.Aim: To compare outcomes of radical treatment for early stage non-small cell lung cancer in a tertiary teaching hospital cohort. To study the ability of the Charlson Comorbidity Index in predicting outcomes.Methods: A retrospective audit of newly diagnosed Stage 1A to 2B NSCLC patients treated radically with surgery and radiotherapy was undertaken over a period of 2007 to 2012.Results: 53 patients underwent surgical management and 52 patients underwent radiotherapy with radical intent. Surgical management included wedge resection, lobectomy and pneumonectomy. Most patients treated with radiotherapy (external beam) were given 60 Gray in 30 Fractions. A significant difference in mortality (adjusted for age and lung function) was observed between the two modalities (favouring surgical treatment). The mean Charlson Comorbidity Index at the time of diagnosis was higher in patients who had adverse outcomes.Conclusion: Surgically treated patients with early stage non-small cell lung cancer have significantly better outcomes when compared to patients treated with radiotherapy with radical intent. The Charlson Comorbidity index could be useful in predicting outcomes.