RT Journal Article
SR Electronic
T1 Improvement in FEV1 after acute COPD exacerbations are driven more by changes in hyperinflation than changes in proximal airway volume
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4612
DO 10.1183/13993003.congress-2015.PA4612
VO 46
IS suppl 59
A1 Van Holsbeke, Cedric
A1 Vos, Wim
A1 Van Geffen, Wouter
A1 Kerstjens, Huib
A1 Pistolesi, Massimo
A1 Usmani, Omar
A1 Hajian, Bita
A1 Cahn, Anthony
A1 De Backer, Jan
A1 De Backer, Wilfried
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/PA4612.abstract
AB Recovering from a COPD exacerbation is typically associated with an improvement in FEV1. The common perception is that FEV1 is determined by the characteristics of the larger airways (generations 2-6).Aims: We investigated the relationship between changes in FEV1, airway volume and lung hyperinflation in patients recovering from an acute COPD exacerbation.Methods: Airway volume and hyperinflation were assessed using a novel imaging method called Functional Respiratory Imaging (FRI) in 50 COPD patients during an acute exacerbation and 6-8 weeks after recovery.Results: A significant correlation was observed between the improvement in FEV1 and the change in FRI based airway volume (R = 0.3, p = 0.045,). However, the change in FEV1 with FRI based hyperinflation was considerably stronger (R = 0.46, p = 0.002).Conclusions: Our data suggest changes in FEV1 after an acute COPD exacerbation are more likely driven by changes in hyperinflation, possibly resulting from small airways inflammation, than larger airway inflammation. We are now evaluating a multiple regression model to determine the contribution of changes in individual FRI based parameters to the overall change in FEV1