TY - JOUR T1 - Effect of cigarette smoke exposure on exhaled nitric oxide and its relation to asthma and hay feverin adult NHANES subjects JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2015.PA4000 VL - 46 IS - suppl 59 SP - PA4000 AU - Tiago Jacinto AU - Andrei Malinovchi AU - Christer Janson AU - João Fonseca AU - Kjell Alving Y1 - 2015/09/01 UR - http://erj.ersjournals.com/content/46/suppl_59/PA4000.abstract N2 - We analysed the effect of cigarette smoke exposure on exhaled nitric oxide (FeNO) and the expected asthma and/or hay fever related increase in FeNO.Subjects (age 18-80 years) from the National Health and Nutrition Examination Survey (NHANES) 2007-2012 datasets were studied. Healthy subjects had no previous diagnosis of asthma, emphysema or chronic bronchitis and reported no hay fever in the past 12 months. COPD was excluded using GOLD criteria. In total 11,677 subjects were included of whom 925 (7.9%) reported asthma and/or hay fever. Total cigarette smoke exposure (passive and active) was measured by serum cotinine. Exposure categories were defined using quartiles. FeNO was measured with NIOX MINO.View this table:Table 1 #P<0.001 compared to the other cotinine quartiles (ANOVA), *P=0.01 and *P<0.001 compared to healthy subjects (Student t-test).In both groups, an effect of cigarette smoke exposure was seen only for the highest quartile of cotinine corresponding to actively smoking at least 10 cigarettes/day. FeNO was significantly higher in the asthma/hay fever group for all cotinine strata but the difference was smaller for the highest stratum.We conclude that cigarette smoke exposure reduces FeNO similarly in healthy subjects and subjects with asthma and/or hay fever, however a difference stills remains between these groups regardless of the degree of exposure. ER -