RT Journal Article
SR Electronic
T1 Longitudinal lung volume data in preterm children from infancy to early childhood
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA4764
DO 10.1183/13993003.congress-2015.OA4764
VO 46
IS suppl 59
A1 Anne Schmidt
A1 Sophie Yammine
A1 Elena Proietti
A1 Oliver Fuchs
A1 Barbara Egger
A1 Claudia Kuehni
A1 Philipp Latzin
A1 Urs Frey
YR 2015
UL http://erj.ersjournals.com/content/46/suppl_59/OA4764.abstract
AB Background: Prematurity disturbs alveolar growth. Previous studies in affected children reported data on lung volumes over short periods, or on airway growth. The aim of this study was to assess lung volumes and potential influencing factors in preterm children from infancy to early childhood.Methods: Functional residual capacity (FRC) was measured in preterm children without sedation in infancy (visit 1) by multiple-breath washout (MBW), and at school age (visit 2) by MBW and plethysmography. FRC at visit 1 was derived from washin with 4% sulphur hexafluoride, maximum tracer concentration was determined by end-inspiratory molar mass. The main outcome was FRC at visit 2 from nitrogen MBW. We tested the association of absolute FRC values at visits 1 and 2 by linear regression analysis.Results: We analysed longitudinal FRC measurements in 71 children (31 females), mean (SD) gestational age at birth and at visit 1 were 29 (3.0) and 45 (2.2) wks., mean (SD) age at visit 2 was 8.8 (1.3) yrs. We adjusted for days of postnatal oxygen supplementation, height z-score, and age at visit 2. In this multivariable model, FRC at visit 1 was associated with FRC at visit 2 (coefficient (95%CI) 3.0 (0.5 – 5.5) ml per ml increase). The model explained 57% of the variance of FRC at visit 2 (p < 0.001), with the highest proportion of variance explained by height and age at visit 2.Conclusion: We found an association of FRC after birth with FRC at school age after adjustment for age and body size at school age, and for immaturity of the lungs at birth. To the best of our knowledge, our study is the first to show longitudinal lung volumes in preterm children in a prospective study from infancy to early childhood.